There seems to be some agreement that the most important attribute required for effective global leadership is a not a new set of skills or experience, but rather a perspective, a mindset (Cohen, 2010). However, the current western conceptualized global mindset might not always be appropriate and applicable in other contexts. It seems that globalization calls for new parameters to construct a global mindset for the twenty-first century. Thus, the aim of my study is to explore the parameters of global mindset. I will seek to understand how a global mindset, as unraveled through transdisciplinarity, could be a response to setting the foundation for the development of individuals into leaders who encounter the complexities of this global reality here and now with appropriate perspectives, approaches, attitudes, and skills. My plan is to create an architecture for the support and development of a transdisciplinary global mindset for global leadership.